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Research Journal of Pharmaceutical Dosage Form and Technology

Year

2014

Authors

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Shaheda Sultana, Sk.

Synthesis of Chalcones and Evaluation of Their Anti-Microbial Activity

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Authors

P. Parveen ¹, P. Usha ¹, V. Vasu Naik ¹, Sk. Shaheda Sultana ¹, M. Gayatri Ramya ²

Affiliations
1 Hindu College of Pharmacy, Amaravathi Road, Guntur-522002, IN
2 University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur-500510, IN

Source

Research Journal of Pharmaceutical Dosage Form and Technology, Vol 6, No 1 (2014), Pagination: 26-32

Abstract

Chalcones are main precursor for biosynthesis of flavonoids which are frequent components of human diet. Recent studies on biological evaluation of chalcones revealed some Anticancer, Anti inflammatory, Anti mitotic, Anti tubercular, Cardiovascular, cell differenciation inducing, nitric oxide regulation modulatory and hyperglycaemic activities. This present research includes synthesis of varies chalcones from 5-acetyl salicylamide and evaluation of their anti microbial activity. Objective:

1. To synthesize chalcones using different catalyst solid NaOH.

2. Characterize chalcones using TLC, NMR, MASS and IR spectrometry.

3. To evaluate the anti-microbial activity .

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